HID-1 is a novel player in the regulation of neuropeptide sorting.
نویسندگان
چکیده
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway. Epistasis analysis suggests that rab-2 is epistatic to hid-1.
منابع مشابه
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 434 3 شماره
صفحات -
تاریخ انتشار 2011